I just handed in my term paper on the developmental sexual dimorphism of the preoptic area of the hypothalmus. Really sounds like a page turner, I know. However, despite the rather dry vocab, sexual differentiation is a truly fascinating process, due in no small part to the voyeuristic, comical, and sometimes sad behavioral testing methods used to measure the effects of various physiological manipulations.
What did you do last night? Oh, watched rats hump each other under a red lamp.
Some of the testing is done under "sub-optimal" conditions, which either means a scary new environment, a less than receptive female (if you feed them a few drinks they stop resisting so much), or, and this is my favorite, restricting access to the receptive female by tethering the male to limit his movement. One tiny little rat harness + one lusty but coy female = some aggravated rats around the water dropper in the morning.
Dude! I was SO ready to go but there was something holding me back. I don't know what it was. Maybe we've just grown apart.
I ended up writing the damn thing in one solid 8 hour stretch because I procrastinated for so fucking long. I had a thorough outline done, but still. Half of me is rather proud of what I managed to pull off, but the other half is kicking myself senseless BECAUSE IT WON'T ALWAYS WORK OUT THAT WAY.
What? You want to fail out of medical school? You want to know only 3/4 of the operation you are doing? You are proud that you have no self-discipline or work ethic? Sit up straight, and eat your breakfast.
Yeah, that part of me is really loud and really annoying.
Oh, one other thing. You might want to read up on the role of COX-II as far as masculinization of the brain during the perinatal period goes. Exposing a perinatal male rat to the potent COX-II inhibitor indomethacina "markedly" impairs adult sexual arousal mechanisms...the poor things just aren't interested when they get older. Latency to mounting? Long. Latency to intromission? Long. Note that's "inTROmission" not "inTERmission". Sadly, there is no half-time show or popcorn in the little tiny rat cages. Honestly, though, there should be SOMETHING to help alleviate the awkward mood. Ejaculation? Never. No word on cuddling.
Why is this relevant, you ask? Well two other (mild) COX inhibitors are asprin and acetaminophen. Yep, rats exposed perinatally to asprin show similar, although reduced, impairment of function as adults. Humans have very similar mechanisms, so the next time you or the guy you're with can't get it up, you can blame it on your/his mother and her filthy asprin addiction (as if you/he hadn't already). And if you're pregnant? How bad is that headache, REALLY? You horrible, horrible mother. See, it always comes down to mothers sucking.
ps. Just in case some fundy out there stumbles across this, mangles the science in their own special way, and starts having urges to go burn down a drugstore - asprin fucks with arousal mechanisms, which are not related to sexual preference. Asprin might make you flaccid and prone to buying sports cars, but it doesn't make Teh Gay.
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